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Empazin M 12.5|500mg 1 Strip
Empazin M 12.5|500 is used as a treatment for adults with type 2 diabetes mellitus.
- Swallow tablets whole with food.
- Do not crush, chew, or break the tablet.
- Take the medication at the same time each day.
- If a dose is missed, take it as soon as remembered.
- Skip the missed dose if it is nearly time for the next one.
- Do not double-dose.
- Not recommended during pregnancy, especially during the 2nd and 3rd trimesters.
- Not advised during breastfeeding as both components may be excreted in breast milk and pose a risk to the infant.
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✅ Description:
Empazin M 12.5/500 is indicated for the management of Type 2 Diabetes Mellitus in adults, as an adjunct to diet and exercise, especially in patients where a combination therapy is appropriate.
This fixed-dose combination works via dual mechanisms:
- Empagliflozin: Inhibits the SGLT2 transporter in the kidneys, promoting urinary excretion of glucose by preventing its reabsorption.
- Metformin: Reduces hepatic glucose production and enhances insulin sensitivity, improving glucose uptake by peripheral tissues.
Together, they synergistically lower blood glucose levels in patients with type 2 diabetes.
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✔️ Side Effects
Common Side Effects
- Nausea, vomiting, diarrhea
- Headache, dizziness, fatigue
- Abdominal pain
- Increased urination, thirst, dry mouth
- Weight loss
Serious Side Effects
- Diabetic ketoacidosis (DKA)
- Lactic acidosis
- Severe hypoglycemia
- Urinary tract infections
- Genital fungal infections
- Dehydration
- Urticaria, dysuria, vaginal infections
✔️ Dosage & Administration
Adult Dose
- Initial dose: Empagliflozin 5 mg + Metformin 500 mg once daily.
- Dose can be titrated gradually based on effectiveness and tolerance.
- Maximum daily dose: Empagliflozin 25 mg + Metformin 2000 mg.
- Should be taken twice daily with meals to minimize gastrointestinal discomfort.
Pediatric Use
- Not recommended for children under 18 years due to a lack of safety and efficacy data.
Renal Impairment
- Contraindicated in patients with eGFR < 45 mL/min/1.73 m².
- Renal function should be assessed prior to initiation and monitored regularly.
✔️ Empagliflozin 12.5mg + Metformin Hydrochloride 500mg May interact with:
- Insulin & sulfonylureas – risk of hypoglycemia
- Thiazolidinediones may worsen heart failure
- Beta-blockers may mask hypoglycemia symptoms
- ACE inhibitors / ARBs/diuretics – may cause hypotension or dehydration
- Steroids/thyroid hormones may alter blood sugar control
- Alpha-glucosidase inhibitors may reduce glucose-lowering efficacy
✔️ Contraindications
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- Severe hepatic impairment
- History of lactic acidosis
- Hypersensitivity to any of the components
- Heart failure, dehydration, active urinary tract infection
- Post-operative or trauma patients
- Elderly patients with multiple comorbidities
✔️ Precautions
- Monitor renal function and hydration status.
- Caution in patients with bladder infections, hypotension, or a history of genital infections.
- Avoid alcohol to reduce the risk of lactic acidosis.
- Increased risk of ketoacidosis during stress, illness, or fasting.
✔️ Storage Conditions
- Store below 30°C, away from moisture and direct light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
