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Empazin M 12.5|500mg 1 Strip
Empazin M 12.5|500 is used as a treatment for adults with type 2 diabetes mellitus.
- Swallow tablets whole with food.
- Do not crush, chew, or break the tablet.
- Take the medication at the same time each day.
- If a dose is missed, take it as soon as remembered.
- Skip the missed dose if it is nearly time for the next one.
- Do not double-dose.
- Not recommended during pregnancy, especially during the 2nd and 3rd trimesters.
- Not advised during breastfeeding as both components may be excreted in breast milk and pose a risk to the infant.
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✅ Description:
Empazin M 12.5/500 is indicated for the management of Type 2 Diabetes Mellitus in adults, as an adjunct to diet and exercise, especially in patients where a combination therapy is appropriate.
This fixed-dose combination works via dual mechanisms:
- Empagliflozin: Inhibits the SGLT2 transporter in the kidneys, promoting urinary excretion of glucose by preventing its reabsorption.
- Metformin: Reduces hepatic glucose production and enhances insulin sensitivity, improving glucose uptake by peripheral tissues.
Together, they synergistically lower blood glucose levels in patients with type 2 diabetes.
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✔️ Side Effects
Common Side Effects
- Nausea, vomiting, diarrhea
- Headache, dizziness, fatigue
- Abdominal pain
- Increased urination, thirst, dry mouth
- Weight loss
Serious Side Effects
- Diabetic ketoacidosis (DKA)
- Lactic acidosis
- Severe hypoglycemia
- Urinary tract infections
- Genital fungal infections
- Dehydration
- Urticaria, dysuria, vaginal infections
✔️ Dosage & Administration
Adult Dose
- Initial dose: Empagliflozin 5 mg + Metformin 500 mg once daily.
- Dose can be titrated gradually based on effectiveness and tolerance.
- Maximum daily dose: Empagliflozin 25 mg + Metformin 2000 mg.
- Should be taken twice daily with meals to minimize gastrointestinal discomfort.
Pediatric Use
- Not recommended for children under 18 years due to a lack of safety and efficacy data.
Renal Impairment
- Contraindicated in patients with eGFR < 45 mL/min/1.73 m².
- Renal function should be assessed prior to initiation and monitored regularly.
✔️ Empagliflozin 12.5mg + Metformin Hydrochloride 500mg May interact with:
- Insulin & sulfonylureas – risk of hypoglycemia
- Thiazolidinediones may worsen heart failure
- Beta-blockers may mask hypoglycemia symptoms
- ACE inhibitors / ARBs/diuretics – may cause hypotension or dehydration
- Steroids/thyroid hormones may alter blood sugar control
- Alpha-glucosidase inhibitors may reduce glucose-lowering efficacy
✔️ Contraindications
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- Severe hepatic impairment
- History of lactic acidosis
- Hypersensitivity to any of the components
- Heart failure, dehydration, active urinary tract infection
- Post-operative or trauma patients
- Elderly patients with multiple comorbidities
✔️ Precautions
- Monitor renal function and hydration status.
- Caution in patients with bladder infections, hypotension, or a history of genital infections.
- Avoid alcohol to reduce the risk of lactic acidosis.
- Increased risk of ketoacidosis during stress, illness, or fasting.
✔️ Storage Conditions
- Store below 30°C, away from moisture and direct light.
- Keep out of reach of children.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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